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vascularization

research at the intersection of design, experimental surgery, and nuclear physics

Emile de Visscher - December 19, 2024

the original language of this article is english

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A recent paradigm shift in materials science and engineering has taken place. The conventional emphasis on strength, durability, and stability generates objects that are difficult to recycle and therefore directly linked to the current ecological crisis. Consequently, researchers in design, engineering, and architecture are now turning their attention to the evolutionary, self-healing, multifunctional, and active capacities of materials that behave just like living organisms. However, in living organisms, these mechanisms are often guided and orchestrated by dendritic or vascular typologies, which support metabolic functions, based on fluid circulation, and the optimization of interactions with the environment.

The resulting project stems from a collaboration between designers, biologists, and surgical researchers aimed at understanding the functioning of vascular structures in organs, and to find new techniques for manufacturing dendritic structures. In the medical field, this research focuses on extracellular matrices (ECMs), the architecture of our organs in which cells can operate. The efficient manufacture of these ECMs is a key challenge for surgical research as a means of mitigating the lack of organ donations.

Inspired by fulgurites, vitreous material formed by lightning striking sand or sediment, we have succeeded in using electrons to tunnel through materials at the micrometric scale. To accomplish this, we required an electron accelerator, which we were able to use at the École Polytechnique in Palaiseau on several occasions. The principle is simple: a block of PMMA (transparent, commonly known as plexiglass) or PLA (bioplastic, green-yellow in color) material to a beam of electrons that are captured in its structure, then given an exit path by a shock from a nail connected to the terrestrial network. Instantaneously, all the electrons are released, forming vascular networks whose pathways are optimized by the process itself. This project, both an investigation into material expression and the development of potential applications, challenges the role of the designer as a mediator between knowledge, technologies, and the discourses of disciplines traditionally considered incommensurable.

Learn more about this project here

credits

author: Emile De Visscher (PhD), Junior Professorship at ENS Paris-Saclay, Université Paris-Saclay / former research associate, Cluster of Excellence Matters of Activity: Image Space Material, Humboldt-Universität, Berlin / EA SACRe, École Nationale supérieure des Arts Décoratifs, Université PSL, Paris

colleagues:
Prof. Dr. Igor Sauer, Director of Experimental Surgery Lab, Charité – Universitätsmedizin, Berlin
Prof. Dr. Marie Weinhart, Director of Weinhart Research Lab, Freie Universität, Berlin

scientific support:
Antonino Alessi, Romain Grasset, and Olivier Cavani, Laboratoire des Solides Irradiés, École Polytechnique, Palaiseau. Marcus Lindner, Weinhart Research Group, Freie Universität, Berlin.
Elisa Seban and Clara Martini, dEmile De Visscher laboratory, La Courneuve.

director, camera and editing: Boris De Visscher
production: CineCeviche, Brussels
voice-over: Sophie Cazimi
additional shots from the Experimental Surgery Lab: courtesy of the Charité – Universitätsmedizin, Berlin

acknowledgments: We are grateful to the French EMIR&A network for provision of irradiation beam time, and for the support of the Cluster of Excellence “Matters of Activity. Image Space Material” funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC 2025 – 390648296.

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scientific and conceptual challenges of the project:

De Visscher, Emile. 2024. “Biocompatible radiations – Designing for the living.” In Toward a New Culture of the Material. Edited by Frank Bauer, Yoonha Kim, Sabine Marienberg, and Wolfgang Schäffner. Berlin: De Gruyter, https://doi.org/10.1515/9783110714883

scientific articles:

Eder, Michaela, Amini Sharhouz, and Peter Fratzl. 2018. “Biological composites-complex structures for functional diversity.” Science 362 (6414): 543–547.

Elomaa, Laura et al. 2020. “Development of GelMA/PCL and dECM/PCL resins for 3D printing of acellular in vitro tissue scaffolds by stereolithography.” Materials Science & Engineering: C, Materials for Biological Applications 112: p.110958.

Everwien, Hannah et al. 2020. “Engineering an Endothelialized, Endocrine Neo-Pancreas: Evaluation of islet functionality in an ex vivo model.” Acta Biomaterialia; 117: pp. 213–225.

Huang, Jen-Huang et al. 2009. “Rapid Fabrication of Bio-inspired 3D Microfluidic Vascular Networks.” Advanced Materials 21: pp. 3567–3571.

Zheng, Hualong, George Chen, and Simon Rowland. 2019. “The influence of AC and DC voltages on electrical treeing in low density polyethylene.” International Journal of Electrical Power & Energy Systems 114, https://doi.org/10.1016/j.ijepes.2019.105386.

further references:

Barad, Karen. 2017. “No Small Matter: Mushroom Clouds, Ecologies of Nothingness, and Strange Topologies of SpaceTimeMattering.” In Arts of Living on a Damaged Planet. Edited by Tsing, Anna et al, G103-G120. Minneapolis: University of Minnesota Press.

Von Bush, Otto. 2022. Making Trouble: Design and Material Activism. Camden: Bloomsburry.

to cite this article

This article is using Chicago format for its references

De Visscher. 2024. “Vascularization: Research at the Intersection of Design, Experimental Surgery, and Nuclear Physics.” .able journalhttps://able-journal.org/vascularization

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